American Association for the Advancement of Science, 1959. First Edition. FIRST ed., ORIGINAL WRAPPERS, THE GENOME ISSUE featuring features articles on technological developments in genome research, clinical applications, and concerns regarding the social impact of rapidly accumulating genetic information. The following papers are included:
Fraser, C. M. et al., “The Minimal Gene Complement of Mycoplasma genitalium,” provided a model of the minimum number of genes needed for independent existence. And “Mycoplasma genitalium genome, report the complete sequencing of the bacterium with the smallest known genome of any self-replicating organism.
Goffeau, Andre, "Life with 482 Genes," discusses the achievement of the above.
Crystal, Ronald et al. "Transfer of Genes to Humans: Early Lessons and Obstacles to Success,” provides an overview of relevant clinical trials and concludes that the therapeutic transfer of genes into humans is feasible and should be pursued. [Two separate reports also in this issue describe efforts to apply gene therapy to people with ADA-SCID, a hereditary, usually fatal disease resulting in a nonfunctioning immune system].
Hudson, K. L. et al., “Genetic Discrimination and Health Insurance,” and "Genetic Discrimination and Health Insurance: An Urgent Need for Reform,” present a series of recommendations for state and federal policymakers including recommendations and definitions suggest that genetic information, including family histories, not be used to establish insurance premiums or eligibility.
Olson, Maynard et al., "A Time to Sequence," argues for an early move to large-scale sequencing of human DNA.
Plasterk, Ronald and Robert Waterson, et al.,present a wall chart [included in this issue] summarizing progress in the project to characterize the genome of the nematode C. elegans. A significant portion of the complete C. elegans DNA sequence has been determined, and its potential for yielding clues to understanding developmental, cell, and neurobiology is already unfolding.
Other Relevant Articles. Other genome-related articles include a story on a new strategy with the potential to analyze proteins directly and see how they change with disease, a report on a chromosome 4 physical map of the flowering plant Arabidopsis thaliana, and two reports describing new approaches to monitoring gene expression. Item #1647
CONDITION & DETAILS: American Association for the Advancement of Science, 1995, Science, Volume 270, Number 5235 : pages 349-548 with illustrations including large wall chart with small tear. Original wrappers, minor wear at edges and remnants of paper from prior attempt to remove address label. Other than the small tear in the wall chart, the interior is pristine. Over all good + condition.